Related Experiment Video

Updated: Oct 12, 2026

Reduced Itraconazole Concentration and Durations Are Successful in Treating Batrachochytrium dendrobatidis Infection in Amphibians
06:49

Reduced Itraconazole Concentration and Durations Are Successful in Treating Batrachochytrium dendrobatidis Infection in Amphibians

Published on: March 14, 2014

[Cotrimoxazole induced dermatitis and curative treatment of AIDS pneumocystosis]

E Caumes1

  • 1Service des Maladies Infectieuses et Tropicales, Hôpital Pitié-Salpètrière, Paris.

Revue Des Maladies Respiratoires
|January 1, 1996
PubMed

Insights

Adverse cutaneous reactions are common during trimethoprim-sulfamethoxazole treatment for pneumocystosis in AIDS patients. Adjuvant corticosteroid therapy can reduce the frequency of these reactions.

Area of Science:

  • Pharmacology
  • Dermatology
  • Infectious Diseases

Context:

  • Trimethoprim-sulfamethoxazole is a primary treatment for Pneumocystis pneumonia (PCP) in individuals with Acquired Immunodeficiency Syndrome (AIDS).
  • Adverse cutaneous reactions, including maculous rash, are frequent during this treatment.
  • Severe reactions like Stevens-Johnson syndrome and Lyell syndrome can be life-threatening.

Purpose:

  • To identify risk factors for adverse cutaneous reactions during trimethoprim-sulfamethoxazole therapy for PCP in AIDS patients.
  • To evaluate the efficacy of adjuvant corticosteroid therapy in mitigating these reactions.

Summary:

  • Adverse cutaneous reactions are common in AIDS patients treated with trimethoprim-sulfamethoxazole for Pneumocystis pneumonia.
  • Risk factors include slow acetylator phenotype, glutathione deficiency, and a prior history of cutaneous reactions.
  • Adjuvant corticosteroid therapy was found to decrease the incidence of these adverse reactions.

Impact:

  • This research highlights the need for vigilant monitoring of skin reactions during trimethoprim-sulfamethoxazole treatment for PCP in AIDS patients.
  • Findings suggest that corticosteroid co-administration may be a valuable strategy to improve treatment tolerability and patient safety.
  • Understanding risk factors can aid in personalized treatment approaches and prevention strategies for adverse drug reactions.

More Related Videos

Curcuminoid-Mediated Antimicrobial Photodynamic Therapy on a Murine Model of Oral Candidiasis06:39

Curcuminoid-Mediated Antimicrobial Photodynamic Therapy on a Murine Model of Oral Candidiasis

Published on: October 27, 2023

Related Concept Videos

Drugs for Treatment of Crohn's Disease in IBD Using Immunomodulatory Agents01:29

Drugs for Treatment of Crohn's Disease in IBD Using Immunomodulatory Agents

Crohn's disease is an inflammatory bowel disorder marked by chronic inflammation of the GI tract. Various treatment strategies for Crohn's disease are employed, such as immunomodulatory agents, glucocorticoids, and biologics or anti-TNF therapy. Azathioprine (Imuran), a commonly used immunomodulatory drug for Crohn's disease, is converted in the body to mercaptopurine, which inhibits purine biosynthesis and cell proliferation. Both are utilized in severe cases of Inflammatory Bowel Disease...
Pulmonary Tuberculosis I01:29

Pulmonary Tuberculosis I

Tuberculosis, often called TB, is a contagious illness primarily caused by Mycobacterium tuberculosis. It mainly affects the lung parenchyma but can also impact other body parts.
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
Pulmonary Tuberculosis V01:28

Pulmonary Tuberculosis V

Medical management of tuberculosis (TB) patients involves a comprehensive approach that includes diagnosis, treatment, and monitoring. The specific strategies can vary depending on the type of tuberculosis (latent or active), the patient's overall health status, and other considerations.
Latent tuberculosis infection occurs when TB bacteria are present in a person's body, but are not causing illness or symptoms. It is not contagious, and preventive treatment is crucial to avoid the progression...
Cryptococcal Meningitis01:27

Cryptococcal Meningitis

Cryptococcal meningitis is a life-threatening opportunistic infection predominantly associated with HIV/AIDS, accounting for over 100,000 deaths annually worldwide. However, it also affects individuals with other forms of immunosuppression, including those undergoing immunosuppressive therapy, organ transplant recipients, patients with innate immunodeficiencies, and individuals with hematological disorders. The infection is caused mainly by Cryptococcus neoformans and Cryptococcus gattii,...
Trichomoniasis01:18

Trichomoniasis

Trichomonas vaginalis is a flagellated protozoan parasite and the causative agent of trichomoniasis, one of the most prevalent non-viral sexually transmitted infections in the United States. This extracellular parasite primarily colonizes the lower genitourinary tract in women—particularly the vagina—and in men, the urethra and prostate. Its structural and functional adaptations enable its survival, motility, and pathogenicity within the host environment.Structural Features and Host EntryT.
Antiprotozoal Agents01:21

Antiprotozoal Agents

Leishmaniasis is a widespread parasitic disease caused by several Leishmania species. It affects millions of people each year and remains a major public health problem in endemic regions. First-line treatment relies on pentavalent antimonials, including meglumine antimoniate and sodium stibogluconate. Even so, how these drugs work has not been fully clear, especially their interaction with parasite-specific biochemical pathways. One key target is trypanothione reductase (TR), an enzyme that...