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In Vivo Modeling of the Morbid Human Genome using Danio rerio

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Published on: August 24, 2013

The geneticist's approach to complex disease

S Ghosh¹, F S Collins

¹National Center for Human Genome Research, National Institutes of Health, Bethesda, Maryland 20892-2152, USA.

Annual Review of Medicine

|January 1, 1996

Summary

This summary is machine-generated.

This study outlines methods for investigating the genetics of complex diseases, emphasizing intermediate quantitative traits for dissecting genetic underpinnings. It provides a scientific rationale and guidelines for ongoing genetic research endeavors.

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Area of Science:

Genetics
Complex Diseases
Quantitative Trait Analysis

Background:

Numerous global studies aim to understand complex disease genetics.
Limited literature provides scientific rationale and guidelines for such research.
Complex diseases pose significant challenges in genetic research.

Purpose of the Study:

To describe the methodology and background for studying complex disease genetics.
To provide guidelines for conducting ambitious genetic research endeavors.
To emphasize the analysis of intermediate, heritable, quantitative traits.

Main Methods:

Describing necessary methodology and background for genetic studies.
Discussing data analysis strategies for complex disease genetics.
Presenting a table of ongoing genetic studies.

Main Results:

Provides a framework for the scientific rationale behind genetic studies.
Offers guidelines for data analysis in complex disease genetics.
Highlights the utility of intermediate quantitative traits.

Conclusions:

The analysis of intermediate, heritable, quantitative traits is crucial for dissecting complex disease genetics.
This work serves as a guide for researchers in the field.
Further research is needed to fully elucidate the genetic basis of complex diseases.