[Pharmaceutical technology of Cordaflex tablets]

Area of Science:

• Pharmaceutical technology
• Drug delivery systems
• Formulation science

Context:

• Investigating nifedipine (Cordaflex active ingredient) solubilization and photosensitivity.
• Developing a controlled-release tablet formulation using coprecipitation.
• Utilizing hydrotropic and retardant substances for drug carrier coating.

Purpose:

• To explore the solubilization and photosensitivity of nifedipine.
• To develop and characterize a retard tablet formulation for nifedipine.
• To assess the impact of formulation parameters on drug release and reproducibility.

Summary:

• A coprecipitate was prepared by spraying a solution of nifedipine, a hydrotropic, and a retardant substance onto a carrier.
• The dried granulated material was blended with excipients, compressed into tablets, and coated.
• The ratio of coprecipitating substances directly influenced dissolution, demonstrating predictable control.
• The developed technology exhibited good reproducibility.

Impact:

• Provides a reproducible method for formulating nifedipine retard tablets.
• Offers insights into controlling drug dissolution through formulation design.
• Contributes to the development of advanced drug delivery systems for nifedipine.