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Gilbert syndrome

M L Ellett

    Gastroenterology Nursing : the Official Journal of the Society of Gastroenterology Nurses and Associates
    |May 1, 1996
    PubMed
    Summary

    Gilbert Syndrome (GS) causes mild unconjugated hyperbilirubinemia in otherwise healthy individuals. Understanding GS pathophysiology is crucial for effective patient and family education by nurses.

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    Area of Science:

    • Hepatology
    • Clinical Biochemistry

    Background:

    • Gilbert Syndrome (GS) is a common, benign genetic condition.
    • Characterized by intermittent, mild unconjugated hyperbilirubinemia.
    • Often identified during routine liver function tests.

    Observation:

    • Patients are typically healthy and over one year old.
    • Unconjugated hyperbilirubinemia is the sole abnormality.
    • Referrals to gastroenterologists are common for diagnosis.

    Findings:

    • GS results from reduced uridine 5'-diphospho-glucuronosyltransferase (UGT1A1) activity.
    • This leads to impaired bilirubin conjugation.
    • The condition is hereditary and lifelong.

    Implications:

    • Accurate diagnosis and understanding of GS pathophysiology are essential.
    • Nurses play a key role in patient and family education.
    • Effective education can alleviate patient anxiety and prevent unnecessary investigations.