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Midazolam for intractable hiccup

A Wilcock1, R Twycross

  • 1Oxford Radcliffe Hospital NHS Trust, United Kingdom.

Journal of Pain and Symptom Management
|July 1, 1996
PubMed
Summary
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Intractable hiccups in terminally ill cancer patients were effectively treated with midazolam. This medication provided rapid relief intravenously and sustained symptom control via continuous subcutaneous infusion.

Area of Science:

  • Palliative Care
  • Oncology
  • Pharmacology

Background:

  • Intractable hiccups present a significant challenge in palliative care, causing severe distress to terminally ill patients.
  • Standard therapeutic interventions for persistent hiccups often prove ineffective in advanced cancer cases.

Observation:

  • Two terminally ill cancer patients experienced severe distress due to intractable hiccups.
  • Conventional treatments failed to alleviate their symptoms.

Findings:

  • Intravenous administration of midazolam (5-10 mg) resulted in rapid and complete resolution of hiccups.
  • Continuous subcutaneous infusion of midazolam (40-120 mg/24 hr) effectively managed hiccups for maintenance therapy.

Implications:

Related Experiment Videos

  • Midazolam offers a promising therapeutic option for managing intractable hiccups in palliative oncology.
  • This approach can significantly improve the quality of life for patients with refractory symptoms.
  • Subcutaneous infusion provides a viable route for long-term symptom management in terminally ill patients.