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[Ovarian suppression with Diane 35/50]

D Erdmann1, E M Schindler, A E Schindler

  • 1Abteilung Gynäkologie, Universitätsklinikum Essen.

Geburtshilfe Und Frauenheilkunde
|November 1, 1994
PubMed
Summary
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Diane 35 and Diane 50 effectively suppress ovarian activity and improve androgenic symptoms, regardless of ethinyl oestradiol dosage. Both treatments demonstrate comparable efficacy in hormone profile normalization and clinical outcomes.

Area of Science:

  • Endocrinology
  • Pharmacology
  • Dermatology

Background:

  • Hormonal imbalances and androgen excess contribute to conditions like acne, hirsutism, and alopecia.
  • Combined oral contraceptives containing anti-androgens and oestrogens are frequently prescribed for managing hyperandrogenism.

Purpose of the Study:

  • To compare the efficacy of Diane 35 and Diane 50 in achieving ovarian suppression and improving androgenic symptoms.
  • To investigate whether ethinyl oestradiol dosage influences the therapeutic outcomes of these combined preparations.

Main Methods:

  • Hormone profiles (LH, FSH, prolactin, oestrogens, androgens, SHBG) were analyzed before and after treatment.
  • Androgen symptoms (acne, seborrhoea, alopecia, hirsutism) were monitored during treatment.
  • Hormonal ratios (LH/FSH, E1/E2) and the androgenic index (T/SHBG) were calculated.

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Main Results:

  • Both Diane 35 and Diane 50 led to significant suppression of LH and FSH, with a tendency for increased prolactin.
  • Total and free testosterone levels decreased, while SHBG increased, indicating reduced androgenic activity.
  • Clinical improvements in acne, seborrhoea, alopecia, and hirsutism were observed across all treatment groups.
  • No significant differences in ovarian suppression or clinical effects were found between Diane 35 and Diane 50.

Conclusions:

  • Diane 35 and Diane 50 are effective in managing hyperandrogenic conditions by normalizing hormone profiles and alleviating androgenic symptoms.
  • The dosage of ethinyl oestradiol (0.035 mg vs. 0.050 mg) does not appear to impact the overall efficacy or ovarian suppressive effects of these treatments.