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Radiation dosimetry in human bone using electron paramagnetic resonance

S L Breen1, J J Battista

  • 1Physics Department, London Regional Cancer Center, Ontario Cancer Treatment and Research Foundation, Ontario, Canada.

Physics in Medicine and Biology
|December 1, 1995
PubMed
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Electron paramagnetic resonance (EPR) can measure radiation dose in bone, acting as an integrating dosimeter. While effective in synthetic materials, human bone requires background signal subtraction for accurate dosimetry in radiotherapy applications.

Area of Science:

  • Medical Physics
  • Biophysics
  • Radiotherapy Dosimetry

Background:

  • Accurate bone dosimetry is crucial for optimizing systemic radiotherapy for osseous metastases.
  • Bone functions as an integrating dosimeter, recording skeletal radiation history through trapped electrons in hydroxyapatite.
  • These trapped electrons exhibit long-term stability, making them suitable for retrospective dose assessment.

Purpose of the Study:

  • To investigate the potential of electron paramagnetic resonance (EPR) for measuring radiation dose in bone.
  • To evaluate the linearity and sensitivity of EPR signals in response to radiation dose in both synthetic and human bone samples.
  • To assess the feasibility of using EPR for dosimetry in systemic radiotherapy and teletherapy.

Main Methods:

  • Irradiation of synthetic hydroxyapatite and excised human bone samples with Co-60.

Related Experiment Videos

  • Measurement of EPR spectra at room temperature and 77 K.
  • Analysis of radiation-induced EPR signals and comparison with absorbed dose.
  • Subtraction of background signals in human bone samples to isolate dosimetric information.

    • Main Results:

    • EPR signals in synthetic hydroxyapatite showed a linear increase with absorbed dose from 3 Gy to 200 Gy.
    • Excised human bone exhibited a variable native signal masking the dosimetric signal.
    • After background subtraction, human bone demonstrated a linear dose response comparable to synthetic hydroxyapatite.
    • The lower limit of measurement for irradiated human bone was similar to synthetic hydroxyapatite.

    Conclusions:

    • Bone can serve as an in vivo linear dosimeter for radiotherapy.
    • EPR dosimetry in bone shows promise for improving dose estimation in systemic radiotherapy and teletherapy.
    • Enhanced EPR sensitivity is required for reliable clinical application in bone dosimetry.