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Formulation and in vitro examination of furosemide containing suppositories and preliminary experiences of their
G Regdon1, T Fazekas, G Regdon
1Department of Pharmaceutical Technology, Albert Szent-Györgyi Medical University, Szeged, Hungary.
Die Pharmazie
|February 1, 1996
Abstract:
Rectal suppositories containing furosemide (4-chloro-N-furfuryl-5-sulfamoylanthranilic acid) and furosemide sodium were formulated with various suppository bases. The in vitro drug release of Massa Estarinum 299 proved to be the best from the vehicle having various physical-chemical properties. The diuretic effect of the two suppositories was compared in a prospective, crossover clinical trial including 8 patients. Both preparations have induced an increase of urine flow, which was comparable to the diuretic effect of the tablet.