Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Probucol normalizes cholesteryl ester transfer in IDDM

J D Bagdade1, E Stein, M C Ritter

  • 1Department of Medicine, Rush Medical College, Chicago, Illinois, USA.

Diabetes Care
|October 1, 1995
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The health impact of smokeless tobacco products: a systematic review.

Harm reduction journal·2021
Same author

Identifying symptoms using the drawings of 4-7 year olds with cancer.

European journal of oncology nursing : the official journal of European Oncology Nursing Society·2018
Same author

Esophageal distensibility measurement: impact on clinical management and procedure length.

Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus·2017
Same author

Role of the C-C chemokine receptor-2 in a murine model of injury-induced osteoarthritis.

Osteoarthritis and cartilage·2016
Same author

Relationship of bone mineralization density distribution (BMDD) in cortical and cancellous bone within the iliac crest of healthy premenopausal women.

Calcified tissue international·2014
Same author

The cooperative apartment.

Community mental health journal·2013
Same journal

A Secular Increase in the Incidence of Islet Autoimmunity Among Colorado Children With Moderate-Risk HLA Genotypes.

Diabetes care·2026
Same journal

Clinical and Biochemical Recovery From Immune Checkpoint Inhibitor-Induced Diabetes With Seroconversion of GAD Antibodies.

Diabetes care·2026
Same journal

State Insulin Out-of-Pocket Cap Policies and Estimated Eligible Populations in the United States, 2019-2026.

Diabetes care·2026
Same journal

Genetic Determinants of Macronutrient Intake Are Associated With Specific Food Intake in Youth: A Cohort Study Across Childhood and Adolescence.

Diabetes care·2026
Same journal

A Novel Electronic Medical Record Search Method to Identify Patients With Ketosis-Prone Diabetes: Implications for Discovery of Atypical Diabetes.

Diabetes care·2026
Same journal

Real-Time Continuous Glucose Monitoring Among People With Type 2 Diabetes and End-Stage Kidney Failure Undergoing Maintenance Hemodialysis: A Randomized Clinical Trial.

Diabetes care·2026
See all related articles

Probucol treatment significantly reduced cholesteryl ester transfer (CET) in patients with insulin-dependent diabetes mellitus (IDDM). This antioxidant therapy improved a key marker of cardiovascular risk without negatively impacting glycemic control.

Area of Science:

  • Cardiovascular Research
  • Endocrinology
  • Pharmacology

Background:

  • Cholesteryl ester transfer (CET) is pathologically elevated in insulin-dependent diabetes mellitus (IDDM).
  • Increased CET enriches atherogenic apolipoprotein B lipoproteins with cholesteryl ester (CE).
  • Previous studies showed probucol normalizes CET in hypercholesterolemic patients.

Purpose of the Study:

  • To investigate the efficacy of probucol in normalizing abnormal CET in IDDM patients.
  • To assess the impact of probucol on CET and glycemic control in IDDM.

Main Methods:

  • Eight normolipidemic IDDM patients were treated with probucol (1.0 g/day) for 2 months.
  • CET was measured using mass and isotopic assays before and after treatment.
  • Lipid profiles, lipoprotein A-I, and glycemic control (fructosamine) were monitored.

Related Experiment Videos

Main Results:

  • Before treatment, CET was significantly accelerated in IDDM patients.
  • Probucol treatment dramatically reduced CET (mass assay: -94%; isotopic assay: -22%, P < 0.001).
  • Probucol decreased plasma and HDL2 cholesterol, and lipoprotein A-I levels, while improving glycemic control (fructosamine).

Conclusions:

  • Probucol effectively reversed the functional abnormality of accelerated CET in IDDM.
  • This beneficial effect occurred without adverse impact on glycemic control.
  • Probucol shows potential as a therapeutic agent for managing cardiovascular risk in IDDM.