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The accuracy center of a eukaryotic ribosome
S W Liebman1, Y O Chernoff, R Liu
1Department of Biological Sciences, University of Illinois at Chicago, USA.
Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire
|November 1, 1995
Abstract:
Mutations in yeast ribosomal proteins and ribosomal RNAs have been shown to affect translational fidelity. These mutations include: proteins homologous to Escherichia coli's S4, S5, and S12; a eukaryote specific ribosomal protein; yeast ribosomal rRNA alterations at positions corresponding to 517, 912, and 1054 in 16S E. coli rRNA and to 2658 in the sarcin-ricin domain of 23S E. coli rRNA. Overall there appears to be a remarkable conservation of the accuracy center throughout evolution.