Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Multiple SWItches to turn on chromatin?

C L Peterson1

  • 1Program in Molecular Medicine, University of Biochemistry and Molecular University of Massachusetts Medical Center, Worcester 01605, USA. craig.Peterson@ummed.edu

Current Opinion in Genetics & Development
|April 1, 1996
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The social context of anxiety and depression: exploring the role of anxiety and depression in the lives of Australian adults with epilepsy.

Epilepsy & behavior : E&B·2014
Same author

The INO80 family of chromatin-remodeling enzymes: regulators of histone variant dynamics.

Cold Spring Harbor symposia on quantitative biology·2011
Same author

Relationships between muscle contributions to walking subtasks and functional walking status in persons with post-stroke hemiparesis.

Clinical biomechanics (Bristol, Avon)·2011
Same author

Differential diagnosis between urological and intra-abdominal lesions.

The Journal of the American Osteopathic Association·2010
Same author

Differences in self-selected and fastest-comfortable walking in post-stroke hemiparetic persons.

Gait & posture·2009
Same author

Use of real-time qPCR to quantify members of the unculturable heterotrophic bacterial community in a deep sea marine sponge, Vetulina sp.

Microbial ecology·2007
Same journal

Decoding bipotency: a transient regulatory state bridging totipotency and lineage commitment.

Current opinion in genetics & development·2026
Same journal

Functional immunogenomics and deep clinical phenotyping to resolve the challenges of heterogeneity in mental disorders.

Current opinion in genetics & development·2026
Same journal

Temporal trajectories underlying adult neuronal diversity.

Current opinion in genetics & development·2026
Same journal

Transcription regulation of cell fate plasticity - from embryonic development to tissue regeneration.

Current opinion in genetics & development·2026
Same journal

Shared molecular and cellular programs during regeneration of glandular epithelia.

Current opinion in genetics & development·2026
Same journal

Lineage tracing in human cortical development.

Current opinion in genetics & development·2026
See all related articles

The SWI/SNF complex, a gene regulator, may exist in multiple forms. These distinct complexes might target different genes or aid in DNA repair and recombination, not just transcription.

Area of Science:

  • Molecular Biology
  • Genetics
  • Epigenetics

Background:

  • The SWI/SNF complex is a conserved, multi-subunit assembly crucial for gene regulation.
  • It functions by counteracting chromatin-mediated transcriptional repression.
  • Emerging evidence suggests the existence of multiple, functionally distinct SWI/SNF-like complexes.

Purpose of the Study:

  • To explore the potential for diverse SWI/SNF complexes within cellular systems.
  • To investigate whether different SWI/SNF complexes are directed to specific gene sets.
  • To examine if these complexes remodel chromatin for processes beyond transcription, such as DNA repair or recombination.

Main Methods:

  • This study is primarily theoretical, based on recent research findings.
  • It synthesizes existing data to propose functional diversification of SWI/SNF complexes.

Related Experiment Videos

  • No new experimental data was generated; it's a review and hypothesis-driven analysis.

    • Main Results:

    • The abstract suggests that distinct SWI/SNF complexes may exist.
    • These complexes could be specialized for targeting different sets of genes.
    • Alternative roles in chromatin remodeling for DNA repair and recombination are proposed.

    Conclusions:

    • The SWI/SNF complex family might be more diverse than previously understood.
    • Functional specialization of SWI/SNF complexes could extend beyond transcriptional regulation.
    • Further research is warranted to elucidate the specific roles and targets of different SWI/SNF-like complexes.