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Complex movement disorders induced by fluoxetine

K J Bharucha1, K D Sethi

  • 1Department of Neurology, Medical College of Georgia, Augusta 30912, USA.

Movement Disorders : Official Journal of the Movement Disorder Society
|May 1, 1996
PubMed
Summary
This summary is machine-generated.

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Fluoxetine, an antidepressant, may cause complex movement disorders like myoclonus and chorea. These adverse effects resolved after discontinuing fluoxetine treatment.

Area of Science:

  • Neurology
  • Pharmacology

Background:

  • Selective serotonin reuptake inhibitors (SSRIs) like fluoxetine are widely prescribed for depression.
  • Movement disorders are rare but serious potential adverse effects of psychotropic medications.

Observation:

  • Two patients developed distinct complex movement disorders after prolonged fluoxetine therapy.
  • Case 1: A 72-year-old woman presented with rhythmic palatal movements, myoclonus, chorea, and possible dystonia.
  • Case 2: A 58-year-old man experienced myoclonic jerking and rapid, stereotypic toe movements.

Findings:

  • Fluoxetine-induced movement disorders can manifest as diverse and complex motor symptoms.
  • Complete resolution of symptoms occurred within days of fluoxetine withdrawal in both cases.
  • These specific movement disorder presentations appear to be previously unreported adverse effects of fluoxetine.

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Implications:

  • Clinicians should consider fluoxetine as a potential cause of new-onset movement disorders.
  • Early recognition and discontinuation of fluoxetine may lead to symptom remission.
  • Further research is warranted to elucidate the mechanisms underlying fluoxetine-induced movement abnormalities.