[Effect of erythrocyte membrane structure on the dose dependence of photohemolysis]

The influence of different factors modifying erythrocyte membrane structure on the value of power index of doze dependence of photohemolysis of hematoporphyrin-sensitized erythrocytes has been investigated. It has been established that thermoinduced spectrin aggregation results in increase the index, whereas vesiculation under metabolic exhaustion of erythrocytes greatly decreases value n. A more considerable decrease of the parameter was observed when photohemolysis of erythrocytes was occurred in alkaline medium. It has been shown that the observed decrease of the power index in the latter case is not caused by pH-induced changes of photochemical reactions but by some dark processes. The decrease is possibly brought about by pH-induced conformational changes of protein band 3.