Related Experiment Videos
Benign familial hyperphosphatasemia in Siberian huskies
D F Lawler1, D G Keltner, W E Hoffman
1Department of Pet Nutrition Research, Ralston Purina Co, St Louis, MO 63264, USA.
American Journal of Veterinary Research
|May 1, 1996
Summary
A familial condition in Siberian Husky pups caused markedly high serum alkaline phosphatase (SAP) levels. This benign familial hyperphosphatasemia is inherited and presents no other health issues.
Area of Science:
- Veterinary Genetics
- Canine Health
- Biochemistry
Background:
- Benign familial hyperphosphatasemia is a rare genetic disorder.
- Elevated serum alkaline phosphatase (SAP) can indicate various health issues in dogs.
- Familial conditions require genetic evaluation.
Purpose of the Study:
- To investigate a familial condition of elevated SAP in Siberian Husky pups.
- To characterize the biochemical and genetic basis of hyperphosphatasemia in this cohort.
- To compare affected pups with unaffected littermates and controls.
Main Methods:
- Physical examinations and blood analyses were performed on 56 Siberian Husky pups from 8 litters.
- Evaluated serum alkaline phosphatase (SAP) isoenzymes, electrolytes, calcium, and parathyroid hormone.
- Skeletal radiographs, diet, growth, health, and genealogical data were also assessed.
Main Results:
- 17 of 42 tested pups exhibited markedly high SAP levels, over 5 times greater than controls (P < 0.001).
- Affected pups showed no other clinical, radiological, or biochemical abnormalities.
- The elevated SAP activity was attributed to the bone isoenzyme, with a clear autosomal inheritance pattern.
Conclusions:
- The observed condition in Siberian Huskies resembles human benign, persistent, familial hyperphosphatasemia.
- This familial hyperphosphatasemia should be considered in the differential diagnosis of elevated SAP in young dogs.