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Exercise-induced increase in lipoprotein (a)

I Holme1, P Urdal, S Anderssen

  • 1Ullevaal University Hospital, Life Insurance Companies' Institute for Medical Statistics, Oslo, Norway.

Atherosclerosis
|April 26, 1996
PubMed
Summary
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Physical exercise significantly increased lipoprotein (a) levels in healthy adults. Lifestyle changes, including exercise, may influence lipoprotein (a) more than previously thought.

Area of Science:

  • Cardiovascular Health
  • Exercise Physiology
  • Lipid Metabolism

Background:

  • Coronary risk factors in healthy middle-aged adults often require intervention.
  • Lipoprotein (a) [Lp(a)] is an emerging cardiovascular risk factor.
  • The impact of lifestyle interventions on Lp(a) is not fully understood.

Purpose of the Study:

  • To investigate the effects of diet and exercise interventions on coronary risk factors.
  • To specifically test if physical exercise increases lipoprotein (a) levels.
  • To explore the relationship between lifestyle changes and Lp(a) levels.

Main Methods:

  • Randomized controlled trial with 219 participants.
  • Four intervention groups: diet, exercise, diet + exercise, and control.

Related Experiment Videos

  • Interventions maintained for one year.

    • Main Results:

    • Exercise intervention significantly increased Lp(a) levels by 15.4 mg/l compared to no exercise.
    • Dietary intervention showed a trend towards increasing Lp(a), but not statistically significant.
    • A dose-response relationship existed between exercise intensity (heart rate, peak oxygen uptake) and Lp(a) changes.

    Conclusions:

    • Physical exercise is associated with increased Lp(a) levels.
    • Lp(a) may be more modifiable by lifestyle interventions than previously reported.
    • Changes in Lp(a) correlate with changes in alcohol intake and waist circumference.