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Related Experiment Videos

Persistent thallium-201 defect: can clinical, electrocardiographic and exercise hemodynamic variables predict defect

N W Shammas1, R G Schwartz, R M Pomerantz

  • 1Department of Medicine (Cardiology Unit), University of Rochester, School of Medicine and Dentistry, N.Y., USA.

Cardiology
|May 1, 1996
PubMed
Summary

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Persistent thallium-201 (201Tl) myocardial perfusion defects often normalize on resting reinjection scintigraphy. However, clinical, electrocardiographic, and exercise hemodynamic variables could not predict this normalization in patients with persistent defects.

Area of Science:

  • Cardiology
  • Nuclear Medicine
  • Medical Imaging

Background:

  • Persistent myocardial perfusion defects on thallium-201 (201Tl) scintigraphy are common.
  • Resting reinjection scintigraphy can reveal normalization of these defects.

Purpose of the Study:

  • To assess the predictive value of clinical, electrocardiographic, and exercise hemodynamic variables for normalization of persistent 201Tl myocardial perfusion defects.

Main Methods:

  • 159 patients with persistent 201Tl defects were studied.
  • Patients were classified based on normalization by reinjection scintigraphy.
  • Multiple logistic regression analysis was used to identify predictors of normalization.

Main Results:

  • No significant differences were found between normalized and non-normalized groups regarding gender, angina, rate-pressure product, exercise duration, ECG changes, Q waves, LVH, or number of defects.

Related Experiment Videos

  • Logistic regression analysis did not identify any single variable or combination of variables that predicted defect normalization.

    • Conclusions:

    • Normalization of persistent 201Tl myocardial perfusion defects on resting reinjection scintigraphy is prevalent.
    • Predicting this normalization using available clinical, electrocardiographic, and exercise hemodynamic data is not feasible.