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A Multicenter MRI Protocol for the Evaluation and Quantification of Deep Vein Thrombosis
10:26

A Multicenter MRI Protocol for the Evaluation and Quantification of Deep Vein Thrombosis

Published on: June 2, 2015

Diagnostic significance of thrombin-antithrombin III complex (TAT) and D-dimer in patients with deep venous

H Sassa1, T Sone, H Tsuboi

  • 1Department of Cardiology, Ogaki Municipal Hospital, Japan.

Japanese Circulation Journal
|April 1, 1996
PubMed

Insights

Thrombin-antithrombin III (TAT) and D-dimer are effective biomarkers for diagnosing deep venous thrombosis (DVT). Elevated levels of TAT and D-dimer significantly indicate DVT presence and aid in acute DVT screening.

Area of Science:

  • Vascular Medicine
  • Hematology

Background:

  • Deep venous thrombosis (DVT) is a significant clinical concern.
  • Accurate and timely diagnosis of DVT is crucial for patient outcomes.

Purpose of the Study:

  • To evaluate the diagnostic utility of Thrombin-antithrombin III (TAT) and D-dimer in patients suspected of DVT.
  • To assess the correlation between TAT, D-dimer levels, and ultrasonographically confirmed DVT.

Main Methods:

  • Blood samples were collected from 50 patients with suspected DVT.
  • Thrombin-antithrombin III (TAT) and D-dimer levels were measured.
  • Deep venous thrombosis (DVT) was diagnosed using ultrasonography (compression and Doppler imaging).

Main Results:

  • Patients diagnosed with DVT exhibited significantly higher TAT (20.4 +/- 19.10 micrograms/L) and D-dimer (9.0 +/- 9.21 micrograms/ml) levels compared to those without DVT (TAT: 3.8 +/- 2.36 micrograms/L; D-dimer: 0.7 +/- 0.69 micrograms/ml).
  • A cutoff of TAT >= 7.0 micrograms/L and D-dimer >= 3.0 micrograms/ml demonstrated 84% sensitivity, 96% specificity, and 90% accuracy for DVT diagnosis.
  • Nineteen of 23 DVT cases were acute, presenting within two weeks of symptom onset.

Conclusions:

  • Thrombin-antithrombin III (TAT) and D-dimer are highly valuable biochemical markers for the diagnosis of deep venous thrombosis (DVT).
  • These markers show excellent accuracy, sensitivity, and specificity, making them useful for screening acute DVT cases.

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