Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Reduced glutamine content in colonic polyps

E Goldin1, L Aptekar, J Siguencia

  • 1Dept. of Gastroenterology, Hadassah University Hospital, Hebrew University Medical School, Jerusalem, Israel.

Scandinavian Journal of Gastroenterology
|April 1, 1996
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Arginine Dentifrices and Childhood Caries Prevention: A Randomized Clinical Trial.

JDR clinical and translational research·2025
Same author

Enhancing social functioning using multi-user, immersive virtual reality.

Scientific reports·2025
Same author

CPL-01, an investigational long-acting ropivacaine, demonstrates safety and efficacy in open inguinal hernia repair.

Hernia : the journal of hernias and abdominal wall surgery·2024
Same author

Worsening of psychotic experiences in college students during the COVID-19 pandemic.

Schizophrenia research·2022
Same author

Data Science for Advancing Environmental Science, Engineering, and Technology: Upcoming Special and Virtual Issues in <i>ES</i><i>&T</i> and <i>ES</i><i>&T Letters</i>.

Environmental science & technology·2022
Same author

Modeling regional disease spread over time using a dynamic spatio-temporal model - With an application to porcine epidemic diarrhea virus data in Iowa, US.

Preventive veterinary medicine·2020
Same journal

Textbook outcome after esophagectomy in Norway - a national cohort study of low- to medium-volume centers.

Scandinavian journal of gastroenterology·2026
Same journal

Fecal calprotectin concentration in adults with and without <i>Helicobacter pylori</i> infection.

Scandinavian journal of gastroenterology·2026
Same journal

Endoloop-clip closure versus hemoclips for large sigmoid colon perforations: a randomized controlled <i>ex vivo</i> study.

Scandinavian journal of gastroenterology·2026
Same journal

Outcomes associated with secondary spontaneous bacterial peritonitis (SBP) prophylaxis after hospital discharge in a nation-wide Swedish cohort.

Scandinavian journal of gastroenterology·2026
Same journal

Supra-papillary versus trans-papillary stenting for malignant biliary obstruction: an updated meta-analysis of randomized trials.

Scandinavian journal of gastroenterology·2026
Same journal

Acute upper gastrointestinal bleeding: a population-based cohort study from Southern Iceland.

Scandinavian journal of gastroenterology·2026
See all related articles

Colonic adenomatous polyps show reduced glutamine levels and catabolic enzyme activity. This altered glutamine metabolism may contribute to the development of colon cancer.

Area of Science:

  • Biochemistry
  • Oncology
  • Gastroenterology

Background:

  • Glutamine is the most abundant amino acid, crucial for nitrogen metabolism and cellular energy.
  • It plays a vital role in tumor growth, with altered metabolism observed in cancer patients.

Purpose of the Study:

  • To investigate glutamine catabolism in colonic adenomatous polyps, a premalignant condition.
  • To compare glutamine levels and key enzyme activities between polyps and normal colon tissue.

Main Methods:

  • Quantified free glutamine content in polyp and adjacent normal colon mucosa.
  • Assessed the activity of glutamine transferase and phosphate-dependent glutaminase in both tissues.

Main Results:

  • Significantly lower glutamine content and glutaminase activity were found in polyps compared to adjacent mucosa.

Related Experiment Videos

  • Glutamine transferase activity was also significantly reduced in polyp mucosa.

    • Conclusions:

    • Colonic adenomatous polyps may act as a 'glutamine trap', diverting glutamine towards synthesis pathways.
    • These alterations in glutamine catabolism could be implicated in the pathogenesis of colonic neoplasia.