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Related Experiment Videos

Stromal cell involvement in leukemogenesis and carcinogenesis

J S Greenberger1, M W Epperly, A Zeevi

  • 1Department of Radiation Oncology, University of Pittsburgh Medical Center, PA 15213, USA.

In Vivo (Athens, Greece)
|January 1, 1996
PubMed
Summary

Stromal cells, crucial for organ renewal, can drive cancer development. Targeting these cells, not just cancer cells, may improve cancer therapies.

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Area of Science:

  • Oncology
  • Cell Biology
  • Carcinogenesis

Background:

  • Stromal cells in self-renewing organs are increasingly implicated in carcinogenesis.
  • Irradiated stromal cells influence leukemia development in co-cultured stem cells.
  • Stromal cells may act as tumor promoters via reactive oxygen species and altered molecule production.

Purpose of the Study:

  • To investigate the role of stromal cells in carcinogenesis.
  • To explore molecular mechanisms by which stromal cells affect stem cells.
  • To evaluate therapeutic inhibition of irradiation-induced stromal cell changes.

Main Methods:

  • Co-cultivation of irradiated and non-irradiated murine cells.
  • Analysis of stem cell phenotypic changes (c-fms, growth factors, transcripts).

Related Experiment Videos

  • In vivo irradiation of mouse lungs with and without tumors, measuring TGF-beta.

    • Main Results:

    • Irradiated stromal cells induce phenotypic changes in stem cells.
    • Stromal cells can block apoptosis and induce DNA breaks in stem cells.
    • Irradiation increases TGF-beta release in lung stromal cells, inhibitable by manganese superoxide dismutase.

    Conclusions:

    • Stromal cells play a significant role in leukemogenesis and carcinogenesis.
    • Molecular mechanisms involving ROS, altered molecules, and TGF-beta are key.
    • Therapeutic strategies should consider targeting stromal cells for effective cancer treatment.