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Dicentric Y chromosome without evidence of mosaicism in an azoospermic male
I Sasagawa1, M Ishigooka, T Kato
1Department of Urology, Yamagata University, School of Medicine, Japan.
Scandinavian Journal of Urology and Nephrology
|February 1, 1996
Abstract:
A phenotypically male of dicentric Y chromosome with no evidence of sex chromosomal mosaicism is reported. Staining of fluorescence in situ hybridization using Y chromosome centromere-specific DNA probe showed the presence of two bright fluorescent spots in Y chromosome. Testicular histology revealed maturation arrest at the stage of primary spermatocyte. It is suggested that structural anomaly of the Y chromosome is related to the disturbance of spermatogenesis.