Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Chicken CP49: significant or paltry? An evolutionary perspective

P S Wallace1, S V Duff, A R Prescott

  • 1Department of Biochemistry, University of Dundee, Scotland, UK.

Ophthalmic Research
|January 1, 1996
PubMed
Summary

Researchers identified a unique CP49 protein variant (CP49ins) in chick lenses, similar to invertebrate intermediate filaments. This finding raises questions about protein assembly and evolutionary links between chick and invertebrate intermediate filament proteins.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Lens Epithelial Cell Proliferation in Response to Ionizing Radiation.

Radiation research·2021
Same author

Dotting the eyes: mouse strain dependency of the lens epithelium to low dose radiation-induced DNA damage.

International journal of radiation biology·2018
Same author

Heat shock proteins are differentially expressed in brain and spinal cord: implications for multiple sclerosis.

Clinical and experimental immunology·2018
Same author

Using Contingent Reinforcement to Augment Muscle Activation After Perinatal Brachial Plexus Injury: A Pilot Study.

Physical & occupational therapy in pediatrics·2017
Same author

THE IMPACT OF CIRCADIAN RHYTHMS ON MEDICAL IMAGING AND RADIOTHERAPY REGIMES FOR THE PAEDIATRIC PATIENT.

Radiation protection dosimetry·2016
Same author

The lens of the eye: exposures in the UK medical sector and mechanistic studies of radiation effects.

Annals of the ICRP·2015

Area of Science:

  • Cell Biology
  • Evolutionary Biology
  • Biochemistry

Background:

  • Lens-specific intermediate filament (IF) proteins, CP49 and filensin, are found across diverse species.
  • Both CP49 and filensin have been identified in the chick lens.
  • A novel variant, CP49ins, featuring a 49-amino acid insertion in helix 1b, has been recently discovered in the chick lens.

Purpose of the Study:

  • To investigate the characteristics of the CP49ins variant.
  • To explore the implications of CP49ins for the co-assembly of CP49 forms in the chick lens.
  • To understand the evolutionary relationship between chick and invertebrate IF proteins.

Main Methods:

  • Protein identification and characterization.
  • Comparative sequence analysis.

Related Experiment Videos

  • In vitro or in vivo assembly studies (implied).

    • Main Results:

    • CP49ins exhibits characteristics resembling invertebrate lamin-like cytoplasmic IFs due to its unique insertion.
    • The presence of CP49ins suggests potential complexities in IF protein interactions within the chick lens.

    Conclusions:

    • The discovery of CP49ins in chick lenses necessitates further research into its assembly dynamics with other CP49 forms.
    • This variant provides a potential model for studying the evolutionary divergence and conservation of IF proteins across species.