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Related Experiment Videos

Acid-base balance with different CAPD solutions

M Feriani1, C Ronco, G La Greca

  • 1Department of Nephrology, St. Bortolo Hospital, Vicenza, Italy.

Peritoneal Dialysis International : Journal of the International Society for Peritoneal Dialysis
|January 1, 1996
PubMed
Summary
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Continuous ambulatory peritoneal dialysis (CAPD) patients

Area of Science:

  • Nephrology
  • Biochemistry

Background:

  • Acid-base balance is crucial for patients undergoing continuous ambulatory peritoneal dialysis (CAPD).
  • Lactate and bicarbonate buffers are commonly used in CAPD solutions to manage acid-base disorders.
  • Understanding buffer fluxes and their impact on body base balance is essential for optimizing CAPD therapy.

Purpose of the Study:

  • To investigate transperitoneal buffer fluxes using lactate and bicarbonate solutions in CAPD.
  • To compare the effects of lactate and bicarbonate buffers on the body base balance of CAPD patients.
  • To determine factors influencing net dialytic base gain and body base balance.

Main Methods:

  • Conducted 104 CAPD exchanges in 52 stable patients with varying dwell times.
  • Measured dialysate effluent lactate, bicarbonate, and volumes.

Related Experiment Videos

  • Calculated net dialytic base gain and assessed patients' acid-base status and plasma lactate levels.

    • Main Results:

    • Lactate buffer: effluent lactate inversely correlated with dwell time, independent of plasma lactate and ultrafiltration.
    • Bicarbonate buffer: effluent bicarbonate correlated with plasma bicarbonate and dwell time, independent of ultrafiltration.
    • Ultrafiltration significantly impacted net dialytic base gain for both buffer types.
    • Net dialytic base gain and metabolic acid production determine body base balance, showing self-regulation via plasma bicarbonate feedback.

    Conclusions:

    • Both lactate- and bicarbonate-buffered CAPD solutions are effective in correcting acid-base disorders.
    • Ultrafiltration is a key factor influencing net dialytic base gain.
    • Body base balance in CAPD patients is self-regulated, explaining interpatient variability in acid-base correction.