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Related Experiment Videos

Age-related changes in the accommodation mechanism

A P Beers1, G L van der Heijde

  • 1Department of Opthalmology, Free University Hospital, Amsterdam, The Netherlands.

Optometry and Vision Science : Official Publication of the American Academy of Optometry
|April 1, 1996
PubMed
Summary

Presbyopia, or age-related farsightedness, is linked to changes in the eye's lens. This study found that both far-to-near and near-to-far focusing speeds slow down with age, supporting a lens-based cause for presbyopia.

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Area of Science:

  • Ophthalmology
  • Biophysics
  • Gerontology

Background:

  • Presbyopia, characterized by age-related loss of near vision, is traditionally attributed to changes in the lens or choroid.
  • Accommodation dynamics, the process of focusing on near objects, differ between far-to-near (FN) and near-to-far (NF) movements.
  • FN dynamics are primarily lens-driven, while NF dynamics involve both lens and choroidal properties.

Purpose of the Study:

  • To investigate the age-related changes in accommodation dynamics.
  • To elucidate the specific contributions of the lens and choroid to presbyopia.
  • To analyze how FN and NF accommodation dynamics change with increasing age.

Main Methods:

  • In vivo measurement of axial lens thickness changes during accommodation using continuous ultrasonographic biometry.

Related Experiment Videos

  • Application of a biomechanical model to analyze accommodation mechanism.
  • Fitting the biomechanical model to accommodative responses to determine time constants and damping coefficients.

    • Main Results:

    • Both FN and NF accommodation time constants increase with age, at comparable rates of approximately 7 ms/year and 6 ms/year, respectively.
    • The lens damping coefficient increases significantly (20-fold) between the ages of 15 and 55.
    • These findings suggest a primary role for the aging lens in presbyopia development.

    Conclusions:

    • The age-dependent slowing of both FN and NF accommodation dynamics supports a lenticular origin for presbyopia.
    • Increased lens damping with age is a key factor contributing to reduced accommodative amplitude.
    • Further research into lens biomechanics is crucial for understanding and potentially treating presbyopia.