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Related Experiment Videos

[Cold-induced cardiac abnormalities in systemic sclerosis]

R H Rey1, G Marrero, A Chwojnik

  • 1Facultad de Medicina, Hospital de Clínicas José de San Martín, Buenos Aires, Argentina.

Medicina
|January 1, 1995
PubMed
Summary
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Systemic sclerosis (SS) patients show early cardiac dysfunction, including impaired ventricular function and wall motion, after cold exposure. This suggests coronary Raynaud

Area of Science:

  • Cardiology
  • Rheumatology
  • Medical Imaging

Context:

  • Systemic sclerosis (SS) frequently causes cardiac abnormalities.
  • Coronary Raynaud's phenomenon may contribute to myocardial dysfunction in SS.
  • Early cardiac dysfunction in SS often lacks overt symptoms.

Purpose:

  • To assess ventricular performance and regional wall motion during cold exposure in SS patients with Raynaud's phenomenon.
  • To investigate potential early signs of cardiac involvement in systemic sclerosis.

Summary:

  • Radionuclide ventriculograms (RV) were performed on 24 SS patients and 10 controls during basal, cold-challenged, and recovery phases.
  • Left ventricular ejection fraction (LVEF) decreased significantly (p=0.03) with reversible wall motion abnormalities post-chilling.

Related Experiment Videos

  • Right ventricular ejection fraction (RVEF) was lower in SS patients at baseline (p=0.02) and decreased with cold exposure (p=0.04).

    • Impact:

    • Demonstrates early cardiac dysfunction and impaired wall motion in response to cold in SS patients.
    • Suggests coronary artery spasm is an early and frequent phenomenon in systemic sclerosis.
    • Highlights the potential for identifying subclinical cardiac disease before symptomatic presentation.