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Experimental autoimmune myocarditis: a suitable model to study neuroimmune crosstalk
C P Leiros1, L Sterin-Borda, N Goren
1Centro de Estudios Farmacologicos y Botanicos (CEFYBO) - CONICET y Catedra de Farmacologia, Facultad de Odontologia, Universidad de Buenos Aires, Argentina.
Acta Physiologica, Pharmacologica Et Therapeutica Latinoamericana : Organo De La Asociacion Latinoamericana De Ciencias Fisiologicas Y [De] La Asociacion Latinoamericana De Farmacologia
|January 1, 1995
Summary
This review explores how autoimmune responses, particularly T lymphocytes and autoantibodies, cause cardiac dysfunction. It highlights the link between immune responses and heart problems, useful for studying neuroimmune interactions in heart failure.
Area of Science:
- Cardiovascular Science
- Immunology
- Neuroscience
Background:
- Autoimmune responses targeting the heart can lead to cardiac dysfunction.
- Understanding the mechanisms of immune-mediated heart damage is crucial for developing effective treatments.
Purpose of the Study:
- To review the functional characteristics of hearts affected by autoimmune responses.
- To elucidate the roles of T lymphocytes and autoantibodies in cardiac dysfunction.
- To explore the utility of autoimmune heart disease models in studying neuroimmune interactions.
Main Methods:
- Comparative analysis of autoimmune myocarditis models with induced myocarditis (viral, parasitic, heart inoculation).
- Evaluation of cardiac damage through histologic, immunologic, biochemical, pharmacologic, and physiologic assessments.
- Review of existing literature on immune-mediated cardiac dysfunction.
Main Results:
- A strong association exists between the onset and progression of immune responses and cardiac dysfunction.
- Autoimmune responses significantly contribute to the development of cardiac dysfunction.
- Cardiac damage manifests through various observable aspects, including histologic and functional changes.
Conclusions:
- Autoimmune heart disease models are valuable for understanding cardiac dysfunction.
- T lymphocytes and autoantibodies play critical roles in the pathogenesis of autoimmune heart disease.
- These models offer insights into neuroimmune interactions, particularly the immune-to-nervous system direction in cardiac failure.