Fluoxetin-induced pulmonary granulomatosis
Related Experiment Video
Updated: Nov 5, 2026

Refined Murine Model of Idiopathic Pulmonary Fibrosis
Published on: June 17, 2025
E de Kerviler1, J Trédaniel, G Revlon
1Service de Radiologie, Hôpital Saint-Louis, Paris, France.
Abstract:
A patient treated with fluoxetin for a manic depressive disorder developed pulmonary inflammatory nodules with noncaseating giant cell granulomas, interstitial pneumonia and non-necrotizing vasculitis, whilst remaining asymptomatic. A progressive resolution of pulmonary nodules occurred after withdrawal of the offending agent, and the chest radiograph returned to normal in 9 months. The diagnosis was assessed by an open lung biopsy.
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