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[Study on ultrastructure of platelets in migraine patients with blood stasis type]
Abstract:
To study the relationship between ultrastructure of platelets and migraine patients with blood stasis type (MBS). The morphologic appearance and aggregation of platelets in MBS patients were examined before and after treatment with Tongbike oral liquor (20 cases in treated group and.10 in control). The results showed that the MBS patients' platelets appeared irregular, easy to aggregate and adhere to red cells, which was more severe when ADP was added, but improved after treated with Chinese medicinal herbs. According to the results it was assumed that platelets from MBS patients were in an abnormal activated state, the abnormal morphology and functional disturbance might be the pathologic basis of MBS. Tongbike oral liquor could markedly improve the morphologic and functional state of platelets, which was relevant to the inhibition of platelet aggregation and the inducing of platelet depolymerization.
Insights
Platelets in migraine with blood stasis patients show abnormal morphology and aggregation. Treatment with Tongbike oral liquor improved platelet function, suggesting a therapeutic role for this Chinese herbal medicine.
Area of Science:
- Hematology
- Pathology
- Traditional Chinese Medicine
Context:
- Migraine with blood stasis (MBS) is a subtype of migraine.
- Platelet morphology and function are implicated in various vascular disorders.
Purpose:
- To investigate the ultrastructural changes in platelets of patients with MBS.
- To evaluate the effect of Tongbike oral liquor on platelet morphology and aggregation in MBS patients.
Summary:
- Platelets from MBS patients exhibited irregular morphology and increased aggregation, particularly when stimulated with ADP.
- These abnormalities improved after treatment with Tongbike oral liquor, a Chinese herbal preparation.
- The findings suggest that platelets in MBS patients are in an abnormally activated state, contributing to the condition's pathology.
Impact:
- This study provides insights into the role of platelet dysfunction in MBS.
- Tongbike oral liquor demonstrates potential as a therapeutic agent for improving platelet function in MBS patients.
- The results support the hypothesis that normalizing platelet morphology and function is key to managing MBS.