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Menorest: technical development and pharmacokinetic profile

J P Marty1

  • 1Laboratory of Dermopharmacology, Faculty of Pharmacy, University Paris-South, Chatenay-Malabry, France.

European Journal of Obstetrics, Gynecology, and Reproductive Biology
|April 1, 1996
PubMed
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Menorest, a new transdermal oestradiol patch, offers consistent drug delivery and maintains therapeutic levels for 84 hours. This innovative patch design provides improved pharmacokinetic profiles compared to older reservoir systems.

Area of Science:

  • Endocrinology and Pharmacology
  • Dermatology and Drug Delivery Systems

Background:

  • Transdermal oestradiol offers advantages over oral administration, including lower doses and avoidance of liver first-pass metabolism.
  • First-generation transdermal systems utilized reservoir designs, while newer technologies incorporate drug dispersion within the adhesive matrix.

Purpose of the Study:

  • To evaluate the pharmacokinetic profile and efficacy of Menorest, a novel transdermal oestradiol delivery system.
  • To compare the performance of Menorest with a standard reservoir patch (Estraderm).

Main Methods:

  • Pharmacokinetic studies were conducted using Menorest patches with varying surface areas (25-100 micrograms/day).
  • Plasma oestradiol concentrations were monitored over an 84-hour dosing interval.
  • Comparison was made against the Estraderm reservoir patch.

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Main Results:

  • Menorest demonstrated constant and reproducible transdermal release of oestradiol.
  • A linear relationship was observed between administered oestradiol dose (patch surface area) and plasma concentrations.
  • Menorest maintained plasma oestradiol levels at or above 40 pg/ml throughout the 84-hour interval, outperforming Estraderm.

Conclusions:

  • The innovative matrix dispersion design of Menorest ensures consistent and reliable oestradiol delivery.
  • Menorest offers a cosmetically acceptable and effective transdermal option for oestradiol therapy, maintaining therapeutic concentrations longer than conventional reservoir patches.