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Updated: Aug 6, 2026
07:28
Corneal Epithelial Abrasion with Ocular Burr As a Model for Cornea Wound Healing
Published on: July 10, 2018
Topical analgesia for superficial corneal injuries
A K Brahma1, S Shah, V F Hillier
1Royal Eye Hospital, Manchester, United Kingdom.
Journal of Accident & Emergency Medicine
|May 1, 1996
Summary
Flurbiprofen 0.03% eye drops significantly reduced ocular pain in patients with superficial corneal injuries. This topical non-steroidal anti-inflammatory agent offers superior pain relief compared to standard treatments.
Area of Science:
- Ophthalmology
- Pharmacology
Background:
- Superficial corneal injuries, such as abrasions, commonly cause significant ocular pain.
- Effective pain management is crucial for patient comfort and healing after corneal injuries.
Purpose of the Study:
- To evaluate the efficacy of topical flurbiprofen 0.03% as an analgesic for superficial corneal injuries.
- To compare flurbiprofen's pain-relieving effects against control and other treatments.
Main Methods:
- A randomized controlled trial involving 401 patients with corneal abrasions.
- Patients received polyvinyl alcohol (control), homatropine 2%, flurbiprofen 0.03%, or homatropine followed by flurbiprofen for 48 hours.
- Ocular pain was assessed using a visual analogue scale over 24 hours; oral analgesic use was also recorded.
Main Results:
- Patients treated with flurbiprofen 0.03% exhibited significantly lower pain scores compared to the control group.
- The reduction in pain was statistically significant (P < 0.05) over the 24-hour assessment period.
Conclusions:
- Topical flurbiprofen 0.03% eye drops are an effective analgesic for superficial corneal injuries.
- Flurbiprofen demonstrates superior pain relief compared to traditional treatment options for corneal abrasions.
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