Histamine release in dogs by Emulphor EL620

Area of Science:

• Pharmacology
• Veterinary Medicine
• Toxicology

Background:

• Emulphor EL620 is a non-ionic surfactant used in various formulations.
• Histamine release can cause significant physiological effects, including cardiovascular changes.
• Understanding the physiological impact of Emulphor EL620 is crucial for safety assessments.

Purpose of the Study:

• To investigate the physiological effects of a vehicle containing ethanol and Emulphor EL620.
• To determine the impact of this vehicle on blood pressure and heart rate in anesthetized dogs.
• To explore the potential role of histamine release in mediating these effects.

Main Methods:

• Anesthetized dogs (morphine-chloralose) were administered a vehicle containing ethanol and Emulphor EL620.
• Blood pressure and heart rate were continuously monitored.
• Histamine release was assessed through appropriate biomarkers.

Main Results:

• Administration of the vehicle resulted in a significant decrease in blood pressure.
• A notable increase in heart rate was observed following administration.
• These cardiovascular alterations were correlated with evidence of histamine release.

Conclusions:

• The vehicle containing ethanol and Emulphor EL620 induces significant cardiovascular changes in anesthetized dogs.
• Emulphor EL620 appears to be the primary agent responsible for triggering histamine release.
• The observed hypotension and tachycardia are likely mediated by histamine release.