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The copper complex of captopril is not a superoxide dismutase mimic. Artefacts in DMPO spin trapping
M Bartosz1, J Kedziora, G Bartosz
1Department of Physiology, Military Medical University, lódź, Poland.
Free Radical Research
|May 1, 1996
Abstract:
The effect of captopril and of its copper complex on several superoxide-dependent reactions used to detect and assay superoxide dismutase activity was studied, including pyrogallol and hematoxylin autoxidation and Nitro Blue Tetrazolium reduction. In none of these systems were superoxide dismutase-like properties of captopril/Cu apparent. Captopril/Cu decreased the yield of DMPO-OH adducts generated by KO2 but this effect may be due to the acceleration of the decay of the adduct by captopril/Cu.