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Database for sensorineural hearing loss

A J Fishman1, N Sculerati

  • 1Department of Otolaryngology, New York University School of Medicine, N.Y. 10016, USA.

International Journal of Pediatric Otorhinolaryngology
|April 1, 1996
PubMed
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Researchers are building a cell and DNA bank from deaf children and families to study hereditary deafness. A detailed database tracks clinical data to understand the causes and features of hearing loss.

Area of Science:

  • Genetics
  • Otolaryngology
  • Bioinformatics

Background:

  • Hereditary deafness is a significant cause of hearing loss.
  • Understanding the molecular basis requires comprehensive genetic and clinical data.
  • Existing data collection methods may lack standardization for familial studies.

Purpose of the Study:

  • To present the design and content of a relational database for hereditary deafness.
  • To facilitate the study of the molecular basis of sensorineural hearing loss.
  • To provide a model for clinical data collection in deafness research.

Main Methods:

  • Creation of a biobank with EBV immortalized lymphoblast cell lines and DNA from deaf individuals and relatives.
  • Development of a computerized relational database to record detailed clinical data.

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  • Database organized into sections covering demographics, medical history, audiology, and genetic information.

    • Main Results:

    • Established a comprehensive database correlating clinical features with genetic material.
    • The data model identifies known etiologies and characterizes clinical phenotypes.
    • The database includes extensive information from patient history, examinations, and diagnostic tests.

    Conclusions:

    • The developed database serves as a valuable resource for studying hereditary deafness.
    • This model can be adopted by other researchers and clinicians for standardized data collection.
    • Facilitates genetic research into the molecular underpinnings of hearing loss.