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Gabapentin in refractory partial epilepsy--a trial in India
1Department of Neurology, All India Institute of Medical Sciences, New Delhi, India.
Acta Neurologica Scandinavica
|February 1, 1996
Summary
Gabapentin (GBP) effectively reduced refractory partial seizures in an Indian trial. Over half of patients responded, showing significant seizure reduction with mild side effects.
Area of Science:
- Neurology
- Clinical Pharmacology
Background:
- Refractory partial epilepsy poses treatment challenges.
- Gabapentin (GBP) is an established add-on therapy for epilepsy.
Purpose of the Study:
- To evaluate the efficacy of Gabapentin as an add-on treatment for refractory partial epilepsy in India.
- To assess seizure frequency reduction and patient response rates.
Main Methods:
- An open-label clinical trial was conducted.
- Twenty-six patients with refractory partial seizures received titrated doses of Gabapentin for 3 months.
- Seizure frequency was monitored before and during treatment.
Main Results:
- A significant mean reduction in seizure frequency was observed (15.87 vs 5.80).
- Eighty percent of patients experienced a reduction in seizures, with 50% classified as responders (>50% reduction).
- Responders were significantly younger than non-responders; adverse events were mild (46% incidence).
Conclusions:
- Gabapentin demonstrates efficacy as an add-on treatment for refractory partial epilepsy in the Indian population.
- This study represents one of the first trials of Gabapentin in a developing country, highlighting its potential therapeutic value.