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Growth hormone deficiency in Dubowitz syndrome
Acta Paediatrica Japonica : Overseas Edition
|June 1, 1996
Summary
Dubowitz syndrome can cause severe short stature. This study documents the first case of growth hormone (GH) deficiency in a child with Dubowitz syndrome, who successfully responded to GH therapy.
Area of Science:
- Pediatrics
- Endocrinology
- Genetics
Background:
- Dubowitz syndrome is a rare genetic disorder characterized by severe intrauterine growth retardation and short stature.
- Growth hormone secretory status has not been well-documented in individuals with Dubowitz syndrome.
Observation:
- A pediatric patient diagnosed with Dubowitz syndrome presented with severe short stature.
- The patient exhibited complete growth hormone (GH) deficiency.
Findings:
- This case represents the first documented instance of growth hormone deficiency in a child with Dubowitz syndrome.
- The patient demonstrated a positive response to growth hormone (GH) therapy, indicating its potential efficacy.
Implications:
- This finding suggests that growth hormone deficiency may be an underrecognized feature of Dubowitz syndrome.
- Further investigation into GH deficiency in Dubowitz syndrome is warranted.
- Growth hormone therapy may be a viable treatment option for short stature in affected individuals.