[Effects of topical application of isopropyl unoprostone on refraction and accommodation]

The effect of topical application of prostaglandin-related compound isopropyl unoprostone on refraction and accommodation were examined. Topical application of isopropyl unoprostone obviously reduced the intraocular pressure, but no significant change in refraction was observed. Amplitude of accommodation, i.e., near point and far point of accommodation, were kept unchanged, although isopropyl unoprostone produced a slight hyperopic shift in dark focus of accommodation. These findings suggest that the reduction of intraocular pressure needs to be explained by a mechanism other than the relaxation of ciliary muscles.