Related Experiment Videos

[TNF/TNFR gene and apoptosis]

Y Takeda1, S Gon, H Takei

  • 1Department of Immunology and Parasitology, Yamagata University School of Medicine.

Nihon Rinsho. Japanese Journal of Clinical Medicine
|July 1, 1996
PubMed

Insights

Tumor necrosis factor (TNF) signaling pathways and their role in apoptosis have been clarified by identifying TNF receptor-associated intracellular molecules. This research discusses how these pathways contribute to TNF-induced cell death.

Area of Science:

  • Cellular Biology
  • Molecular Biology
  • Immunology

Context:

  • Tumor necrosis factor (TNF) and its receptors are crucial in cellular responses.
  • Understanding intracellular signaling is key to deciphering TNF's biological effects.
  • Apoptosis, or programmed cell death, is a fundamental biological process regulated by various pathways.

Purpose:

  • To elucidate the intracellular signal transduction pathways activated by TNF receptor engagement.
  • To identify key TNF receptor-associated intracytoplasmic molecules involved in these pathways.
  • To discuss the functional role of these identified pathways in TNF-induced apoptosis.

Summary:

  • Intracellular signal transduction pathways triggered by the interaction of Tumor Necrosis Factor (TNF) with its receptors have been elucidated.
  • This clarification was achieved through the identification of various TNF receptor-associated intracytoplasmic molecules.
  • The study further discusses the potential involvement of these signal transduction pathways in mediating TNF-induced apoptosis.

Impact:

  • Provides a clearer understanding of TNF-mediated cellular signaling.
  • Identifies molecular players in TNF-induced apoptosis, potentially revealing therapeutic targets.
  • Contributes to the fundamental knowledge of cell death regulation and immune responses.

Related Concept Videos