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[Morphofunctional description of protective cell reactions in aspergillosis]
O K Khmel'nitski i1, I A Labunets
1Medical Academy of Postgraduate Medical Training, St Petersburg, Russia.
Abstract:
Pathomorphosis of aspergillosis was studied in 160 male guinea pigs which were given intraperitoneally a small dose (50000 conidia per 1 ml of isotonic sodium chloride solution) of Aspergillus fumigatus. Protective cell reactions under condition of a normal immune resistance are described. Immunological and mycological methods allowed one to reveal a variability of morphological changes at early stages of aspergillosis and to follow the development of secondary immunodeficiency on the disease day 14.
Insights
This study in guinea pigs reveals how Aspergillus fumigatus causes changes in the body. It details early protective responses and the later development of immunodeficiency during aspergillosis.
Area of Science:
- Mycology
- Immunology
- Pathology