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Renal function in long-duration type I diabetes

P Mackin1, J M Macleod, J P New

  • 1Department of Medicine, University of Newcastle, Newcastle Upon Tyne, U.K.

Diabetes Care
|March 1, 1996
PubMed
Summary
This summary is machine-generated.

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Microalbuminuria and impaired renal function are common in long-duration type I diabetes patients, indicating potential progression to end-stage renal failure. Monitoring renal function and reducing tobacco use are crucial for diabetic nephropathy management.

Area of Science:

  • Nephrology
  • Endocrinology
  • Diabetology

Background:

  • Persistent proteinuria is uncommon after 30 years of type I diabetes.
  • The significance of microalbuminuria in long-duration diabetes remains unclear.

Purpose of the Study:

  • To investigate renal function in patients with over 30 years of type I diabetes.
  • To assess the prevalence of microalbuminuria and overt nephropathy in this cohort.

Main Methods:

  • Measured albumin excretion rate (AER), glomerular filtration rate (GFR), and serum creatinine in 140 patients.
  • Assessed for micro/macrovascular complications and factors influencing diabetic renal disease.

Main Results:

  • 23% had microalbuminuria, 4% had overt nephropathy, and 73% were normoalbuminuric.

Related Experiment Videos

  • Microalbuminuric patients showed lower GFR and higher serum creatinine.
  • Serum creatinine and tobacco consumption were independently linked to elevated albumin excretion.

    • Conclusions:

    • A significant proportion of patients exhibit microalbuminuria and impaired renal function, suggesting potential progression to end-stage renal failure.
    • Continued renal function monitoring is essential for these patients.
    • The link between tobacco use and nephropathy highlights the need for smoking cessation in diabetics.