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Collagenous gastritis associated with lymphocytic colitis
G M Groisman1, S Meyers, N Harpaz
1Department of Pathology, Mount Sinai School of Medicine of the City University of New York, New York, USA.
Journal of Clinical Gastroenterology
|March 1, 1996
Summary
Collagenous gastritis, a rare condition with subepithelial fibrosis, is identified in patients with unexplained dyspepsia. This finding may link to other idiopathic enteritides like collagenous colitis.
Area of Science:
- Gastroenterology
- Histopathology
Background:
- Collagenous sprue and collagenous colitis are recognized idiopathic enteritides characterized by subepithelial basement membrane thickening.
- Similar histologic changes in the gastric mucosa are rare, with
- The term collagenous gastritis was recently proposed for refractory gastritis with subepithelial fibrosis.
Observation:
- This study reports a second case of collagenous gastritis in a 35-year-old woman presenting with refractory dyspepsia.
- Unlike the previous case, this patient also exhibited lymphocytic colitis, a form of colitis linked to watery diarrhea.
Findings:
- Collagenous gastritis is characterized by distinctive subepithelial gastric fibrosis.
- The patient's presentation included refractory dyspepsia and concurrent lymphocytic colitis.
Implications:
- Collagenous gastritis appears to be a distinct clinicopathologic entity.
- Histologic examination for collagenous gastritis should be considered in patients with unexplained dyspepsia.
- Further research into this condition may elucidate its etiology and pathogenesis, potentially linking it to other idiopathic enteritides.