Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Blocks database and its applications

J G Henikoff1, S Henikoff

  • 1Fred Hutchinson Cancer Research Center, Seattle, Washington 98104, USA.

Methods in Enzymology
|January 1, 1996
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Histone marks identify novel transcription factors that parse CAR-T subset-of-origin, clinical potential and expansion.

Nature communications·2024
Same author

Orientation of repeating units in Xenopus chromosomal ribosomal DNA: A test of a stochastic model for maintaining intraspecies homogeneity.

Journal of molecular biology·2011
Same author

Summary: The nucleus--a close-knit community of dynamic structures.

Cold Spring Harbor symposia on quantitative biology·2011
Same author

Epigenetic inheritance of centromeres.

Cold Spring Harbor symposia on quantitative biology·2010
Same author

Applying whole-genome studies of epigenetic regulation to study human disease.

Cytogenetic and genome research·2006
Same author

Epigenetics, histone H3 variants, and the inheritance of chromatin states.

Cold Spring Harbor symposia on quantitative biology·2005
Same journal

1,2-Aminothiol-specific conjugation for dual-color fluorescent labeling via ultrafast TAMM conjugates.

Methods in enzymology·2026
Same journal

Nitrone dipoles in bioorthogonal chemistry applications.

Methods in enzymology·2026
Same journal

Bioorthogonal labeling of sialic acid isomers for detection of glycoconjugates by mass spectrometry imaging and microscopy.

Methods in enzymology·2026
Same journal

Bioorthogonal photocatalytic proximity labeling for quantitative mapping of cell-cell interactions.

Methods in enzymology·2026
Same journal

inCu-click: Enabling copper-catalyzed click chemistry inside living cells.

Methods in enzymology·2026
Same journal

Site-specific antibody labeling via endo-S2 mediated Fc glycan remodeling.

Methods in enzymology·2026
See all related articles

The Blocks Database organizes highly conserved protein sequence segments. This resource aids in protein family analysis, substitution matrix derivation, and sequence similarity searches.

Area of Science:

  • Bioinformatics
  • Computational Biology
  • Molecular Biology

Background:

  • Protein families share conserved sequence regions, crucial for function.
  • Identifying these conserved blocks aids in understanding protein evolution and function.
  • The PROTOMAT system automates the identification and database construction of these blocks.

Purpose of the Study:

  • To describe the Blocks Database, a comprehensive collection of conserved protein sequence segments.
  • To detail the methods used for database construction and querying.
  • To highlight the utility of the Blocks Database in various bioinformatics applications.

Main Methods:

  • Automated identification of conserved protein sequence segments using the PROTOMAT system.
  • Construction of the Blocks Database from Prosite documentation.

Related Experiment Videos

  • Database searching using protein or DNA sequences with significance measures.

    • Main Results:

    • The Blocks Database (version 8.0) contains 2884 blocks from 770 protein families.
    • Search queries return significant single and multiple block hits.
    • The database facilitates the derivation of amino acid substitution matrices (e.g., Blosum series).

    Conclusions:

    • The Blocks Database is a valuable resource for protein family analysis and sequence comparison.
    • It provides essential tools for researchers in bioinformatics and molecular biology.
    • Web and email servers offer accessible means to utilize the database and its functions.