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Adenosine-sensitive ventricular tachycardia: a conceptual approach
B B Lerman1, K M Stein, S M Markowitz
1Department of Medicine, New York Hospital-Cornell University Medical Center, New York 10021, USA.
Journal of Cardiovascular Electrophysiology
|June 1, 1996
Summary
Idiopathic ventricular tachycardia (VT) originates from structurally normal ventricles. This review details cAMP-mediated triggered activity in right ventricular outflow tract VT, a common form.
Area of Science:
- Cardiology
- Electrophysiology
- Cardiac Arrhythmias
Background:
- Idiopathic ventricular tachycardia (VT) arises from ventricles without apparent structural abnormalities.
- VT is classified into distinct entities, including reentrant, automatic, and outflow tract forms.
- Right ventricular outflow tract (RVOT) VT constitutes up to 80% of idiopathic VT cases.
Purpose of the Study:
- To review the experimental basis and clinical characteristics of RVOT idiopathic VT.
- To explore the role of cAMP-mediated triggered activity in specific VT forms.
- To elucidate the mechanisms underlying common types of idiopathic VT.
Main Methods:
- Review of accumulated experimental evidence.
- Analysis of clinical characteristics of RVOT VT.
- Subdivision of RVOT VT into repetitive monomorphic and paroxysmal stress-induced types.
Main Results:
- Idiopathic VT encompasses reentrant, automatic, and RVOT origins.
- RVOT VT is further classified into repetitive monomorphic and paroxysmal stress-induced subtypes.
- Evidence suggests cAMP-mediated triggered activity underlies these VT forms.
Conclusions:
- RVOT idiopathic VT is a significant clinical entity.
- cAMP-mediated triggered activity is implicated in the pathogenesis of common idiopathic VT.
- Understanding these mechanisms is crucial for managing patients with idiopathic VT.