[The roles of thalamic nucleus submedius in nociception and pain modulation]

Recent studies on the roles of thalamic nucleus submedius (Sm) in nociception and pain modulation were reviewed in this article in combination with own our works. Results of these studies showed that Sm may be involved in effective-motivational aspects of pain, and that Sm-VLO-PAG may constitute a pathway of nociceptive modulation which may depress the nociceptive inputs at the spinal cord level via the brain-stem descending inhibitory system, thereby mediate a negative feedback regulation of pain.