Genetic abnormalities and oncogenesis

Since the development of carcinoma probably depends on the paralyzed mitotic maturation promoting system present only within the cancer cell's cytoplasm, it must be established within the cytoplasm, not within the nucleus. Hence, genetic abnormalities in the nucleus should not be regarded as responsible for oncogenesis, even though they may always be identified specifically in a certain carcinoma alone and generally be regarded as responsible for the oncogenesis.