Mannosidosis--pathogenesis of lesions in exocrine cells

The finding of zymogen granules within lysosomal storage vesicles in pancreatic exocrine tissue in bovine mannosidosis may explain the widespread vacuolation of exocrine cells in this disease. It is uncertain if they enter the lysosomal system by the process of crinophagy but if so it would indicate that this regulatory mechanism could operate in normal exocrine tissue as well.