Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Changes in the neuronal plasma membrane during synaptogenesis

L Surchev1, V Dontchev, K Ichev

  • 1Department of Anatomy and Histology, Faculty of Medicine, Sofia, Bulgaria.

Cellular and Molecular Biology (Noisy-Le-Grand, France)
|December 1, 1995
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Type 2 Diabetes, Obesity and Their Relation to the Risks of Thyroid Cancer.

Physiological research·2025
Same author

Feasibility of implementation of the early tumor shrinkage as a potential predictive marker to daily clinical practice in patients with RAS wild type metastatic colorectal cancer, treated with cetuximab - a non-interventional observational study.

Klinicka onkologie : casopis Ceske a Slovenske onkologicke spolecnosti·2024
Same author

Age-Related Changes in Proinsulin Processing in Normoglycemic Individuals.

Physiological research·2023
Same author

The fatty acid composition of serum phospholipids in adolescents is associated with body composition in early adulthoods: an eight-year follow-up study.

Physiological research·2022
Same author

Insights into the physiology of C-peptide.

Physiological research·2020
Same author

Plasma levels of adipokines in patients with Alzheimer's disease - where is the "breaking point" in Alzheimer's disease pathogenesis?

Physiological research·2020

Neuronal membranes mature during early development, increasing proteins and cholesterol domains to form functional synaptic membranes. This study tracks these key molecular changes in Wistar rats.

Area of Science:

  • Neuroscience
  • Cell Biology
  • Developmental Biology

Background:

  • Synaptogenesis involves significant neuronal plasma membrane remodeling.
  • Understanding the molecular changes during this period is crucial for neuroscience.

Purpose of the Study:

  • To morphologically investigate in vivo changes of neuronal membrane components during early postnatal synaptogenesis.
  • To characterize the development of integral membrane proteins, cholesterol domains, carbohydrate residues, and anionic sites.

Main Methods:

  • Morphological analysis of rat cerebral cortex.
  • Preparation of growth cones (postnatal days 0-10) and synaptosomes (postnatal days 14-30).
  • Focus on integral membrane proteins, cholesterol, carbohydrate residues, and anionic sites.

Related Experiment Videos

Main Results:

  • Early postnatal neuronal membranes show few intramembranous particles, small cholesterol domains, and scarce lectin-binding/anionic sites.
  • A progressive increase in these components was observed, leading to mature synaptic membranes.
  • Proteins and cholesterol molecules consistently occupied distinct membrane domains throughout development.

Conclusions:

  • Neuronal membrane maturation involves a significant increase in proteins and cholesterol domains.
  • This study elucidates the morphological basis for the development of functional synaptic membranes from immature precursors.