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Microbial colonization of large wounds

H Vindenes1, R Bjerknes

  • 1Department of Plastic Surgery, University of Bergen, Haukeland Hospital, Norway.

Burns : Journal of the International Society for Burn Injuries
|December 1, 1995
PubMed
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Microbial wound colonization in burn patients is dominated by staphylococci early on, shifting to enterococci and gram-negative bacteria later. Understanding these changes is crucial for effective treatment of burn injuries.

Area of Science:

  • Infectious Diseases
  • Microbiology
  • Burn Care

Background:

  • Burn wound infections are a major cause of morbidity and mortality.
  • Understanding the dynamics of microbial colonization is essential for effective treatment strategies.

Purpose of the Study:

  • To investigate the nature of microbial wound colonization in patients with large burns.
  • To determine the changes in microbial flora over time.
  • To assess the antimicrobial resistance patterns of isolated microbes.

Main Methods:

  • Prospective study involving 28 burn patients.
  • Collection of 748 swabs over 141 sampling procedures.
  • Identification of 414 microbial isolates and determination of their antibiotic resistance profiles.

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Main Results:

  • Coagulase-negative staphylococci (21.5%) and Staphylococcus aureus (14%) were the most frequent initial isolates.
  • Pseudomonas aeruginosa (10.9%) and Enterococcus species (11.3%) became more prevalent in later weeks.
  • Significant resistance to aminoglycosides was observed in enterococci (41%) and coagulase-negative staphylococci (36%).

Conclusions:

  • Burn wound colonization evolves over time, with an initial dominance of staphylococci followed by enterococci and gram-negative opportunists.
  • Antimicrobial resistance patterns vary among different microbial species and over time.
  • Clinical management of burn patients should consider the dynamic nature of wound flora and its resistance patterns.