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Post-transplant lymphoproliferative disorder

N Basgoz1, J K Preiksaitis

  • 1Division of Infectious Diseases, Massachusetts General Hospital, Boston, 02114, USA.

Infectious Disease Clinics of North America
|December 1, 1995
PubMed
Summary

Epstein-Barr virus (EBV) causes various diseases. This review covers EBV virology, immunology, and post-transplant lymphoproliferative disorder (PTLD) pathogenesis, risk factors, diagnosis, and prevention.

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Area of Science:

  • Virology
  • Immunology
  • Transplantation Medicine

Background:

  • Epstein-Barr virus (EBV) is a ubiquitous human herpesvirus.
  • EBV infection is associated with a spectrum of diseases.
  • Understanding EBV's role in post-transplant lymphoproliferative disorder (PTLD) is critical.

Purpose of the Study:

  • To discuss the virology and immunology of Epstein-Barr virus (EBV).
  • To review disease states linked to EBV.
  • To summarize current knowledge on PTLD, focusing on EBV's role.

Main Methods:

  • Literature review of EBV virology and immunology.
  • Analysis of disease states associated with EBV.
  • Synthesis of data on PTLD pathogenesis, risk factors, diagnosis, and treatment.

Main Results:

  • EBV virology and immunology influence disease outcomes.
  • EBV is implicated in the pathogenesis of PTLD.
  • Key aspects of PTLD, including risk factors and management, are detailed.

Conclusions:

  • EBV infection has diverse clinical manifestations.
  • Effective control of EBV in normal hosts relies on robust immunology.
  • Comprehensive strategies are needed for PTLD prevention and treatment.

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