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Updated: Aug 3, 2026

Bioluminescence Imaging of NADPH Oxidase Activity in Different Animal Models
Published on: October 22, 2012
NADPH oxidase and the respiratory burst
1Department of Medicine, University College London, UK.
Abstract:
Phagocytic cells possess an electron-transport system which accepts electrons from NADPH in the cytosol to reduce oxygen to the superoxide radical in the vacuolar lumen. The superoxide is instrumental in killing ingested microorganisms. Patients suffering from chronic granulomatous disease (CGD), in which this system is failing, are abnormally susceptible to infectious diseases. Studying CGD patients' neutrophils has been enormously helpful in identifying the components of the superoxide-generating system, known as the NADPH oxidase. This review will describe the components of the electron-transport chain involved in the oxidase and the factors needed for its regulation.
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