Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Signalling heterogeneity as a contributing factor in macrophage functional diversity

D W Riches1

  • 1Department of Pediatrics, National Jewish Center for Immunology and Respiratory Medicine, Denver, CO 80206, USA.

Seminars in Cell Biology
|December 1, 1995
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Lung B cells promote early pathogen dissemination and hasten death from inhalation anthrax.

Mucosal immunology·2012
Same author

Heterogeneity in the phosphorylation of human death receptors by p42(mapk/erk2).

Biochemical and biophysical research communications·2001
Same author

Beclomethasone diproprionate reduced airway inflammation without adrenal suppression in young children with cystic fibrosis: a pilot study.

Pediatric pulmonology·2001
Same author

Redox paradox: effect of N-acetylcysteine and serum on oxidation reduction-sensitive mitogen-activated protein kinase signaling pathways.

American journal of respiratory cell and molecular biology·2001
Same author

Phosphorylation of the tumor necrosis factor receptor CD120a (p55) recruits Bcl-2 and protects against apoptosis.

The Journal of biological chemistry·2001
Same author

Induction of inducible nitric oxide synthase-NO* by lipoarabinomannan of Mycobacterium tuberculosis is mediated by MEK1-ERK, MKK7-JNK, and NF-kappaB signaling pathways.

Infection and immunity·2001
Same journal

Granulocyte clearance by apoptosis in the resolution of inflammation.

Seminars in cell biology·1995
Same journal

Neutrophil proteinases and matrix degradation. The cell biology of pericellular proteolysis.

Seminars in cell biology·1995
Same journal

NADPH oxidase and the respiratory burst.

Seminars in cell biology·1995
Same journal

Intracellular signaling in neutrophil priming and activation.

Seminars in cell biology·1995
Same journal

Granulocyte adhesion molecules--structure/function relationships.

Seminars in cell biology·1995
Same journal

Expression and biology of neutrophil and endothelial cell-derived chemokines.

Seminars in cell biology·1995
See all related articles

This study explores how diverse macrophage functions emerge from a uniform cell origin. It investigates how stimuli like cytokines drive adaptive changes in macrophage behavior through signaling pathways and gene expression.

Area of Science:

  • Immunology
  • Cell Biology
  • Molecular Biology

Background:

  • Macrophages play crucial roles in host defense and immunity.
  • Despite their diverse functions, macrophages originate from a homogeneous precursor cell population.

Purpose of the Study:

  • To elucidate the mechanisms underlying functional heterogeneity in monocyte-derived macrophages.
  • To examine how stimuli, particularly cytokines, regulate macrophage functions adaptively.

Main Methods:

  • Focus on mechanisms of functional heterogeneity in macrophages.
  • Analysis of how cytokines regulate macrophage functions.
  • Investigation of signaling events leading to gene expression diversity.

Main Results:

Related Experiment Videos

  • Macrophage functional diversity arises from precursor cells.
  • Cytokines act as key regulators of adaptive macrophage functions.
  • Heterogeneity in signaling pathways drives diverse gene expression.

Conclusions:

  • Functional heterogeneity in macrophages is a key aspect of immune response.
  • Adaptive regulation of macrophage functions is crucial for host defense.
  • Signaling pathway diversity is central to macrophage functional specialization.