Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Conversion to tacrolimus after liver transplantation

S Jonas1, W O Bechstein, H P Lemmens

  • 1Chirurgische Klinik, Virchow Klinikum, Humboldt Universität, Berlin, Germany.

Transplant International : Official Journal of the European Society for Organ Transplantation
|January 1, 1996
PubMed
Summary

Tacrolimus rescue therapy is effective for liver transplant patients with severe rejection unresponsive to standard treatments. While generally safe and efficient, its benefit is limited in certain chronic rejection cases, necessitating careful patient selection.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Observation versus late reintroduction of letrozole as adjuvant endocrine therapy for hormone receptor-positive breast cancer (ANZ0501 LATER): an open-label randomised, controlled trial.

Annals of oncology : official journal of the European Society for Medical Oncology·2016
Same author

[Delayed oesophagectomy in diffuse leiomyomatosis].

Zentralblatt fur Chirurgie·2010
Same author

[Skin abscesses in kindergarten children: severe courses due to Panton-Valentine leukocidin producing S. aureus].

Klinische Padiatrie·2010
Same author

[Prolonged remission after immunotherapy of a previously refractory peripheral T-cell non-Hodgkin lymphoma].

Deutsche medizinische Wochenschrift (1946)·2006
Same author

Routine screening of donor hearts by coronary angiography is feasible.

Transplantation proceedings·2006
Same author

Does contrast medium administration in organ donors affect early kidney graft function?

Transplantation proceedings·2006

Area of Science:

  • Nephrology
  • Immunology
  • Transplantation Medicine

Background:

  • Liver transplantation is a complex procedure with potential complications.
  • Rejection episodes remain a significant challenge, impacting graft survival.
  • Tacrolimus is an immunosuppressive drug used in transplantation.

Purpose of the Study:

  • To evaluate the efficacy and safety of tacrolimus as a rescue therapy in liver transplant recipients.
  • To identify specific rejection types where tacrolimus conversion is most beneficial.
  • To explore potential predictive parameters for tacrolimus treatment success.

Main Methods:

  • Retrospective review of 435 liver transplantations.
  • Analysis of tacrolimus use as a rescue agent in 33 patients.

Related Experiment Videos

  • Categorization of indications for rescue therapy, including various rejection types.
  • Assessment of patient and graft survival rates.
  • Comparison of serum bilirubin levels in successful versus unsuccessful tacrolimus therapy.

    • Main Results:

    • Tacrolimus rescue therapy showed an 88% response rate in 33 patients.
    • Patient and graft survival rates were 76% and 70%, respectively.
    • Graft loss occurred in a higher proportion of patients with chronic rejection.
    • Lower serum bilirubin levels correlated with successful tacrolimus therapy in severe steroid-resistant rejection.

    Conclusions:

    • Tacrolimus rescue therapy is a safe and effective option for high-risk liver transplant patients with refractory rejection.
    • Conversion to tacrolimus offers limited benefit in severe steroid-resistant and chronic ductopenic rejections.
    • Further research is needed to identify predictive markers, such as serum bilirubin, to guide treatment decisions and select appropriate candidates for tacrolimus or retransplantation.